Side Effects of the Moderna COVID-19 Vaccine

Side Effects of the Moderna COVID-19 Vaccine

All statistics and data are based on publicly available data at the time of publication. Therefore, some information may be outdated. Visit our COVID-19 hub for the latest information on the pandemic.


At least 219.8 million people have been vaccinated in the United States since the FDA issued the emergency use authorization for the Moderna vaccine shot on December 18, 2020.

Clinical trials conducted on the Moderna found that fatigue, injection site pain, aches, headache, and pains were common complaints after vaccination.

With the increasing number of shots, we’ve been able to analyze the side effects caused by the Moderna vaccine.

Like those who underwent the clinical trials, many people have reported injection site pain, headache, chills, and fever.

Many reports of “COVID arm” after vaccination with Moderna have been received. The COVID arm is a harmless skin rash caused by ingredients in the vaccine.

The reactions are higher after the second dose and in people who have already had COVID-19.

Infectious disease specialists say that these reactions are normal, indicating that your immune system is working as it should – learning to recognize the coronavirus and fight it.


The commonest side effects after receiving the Moderna shot

Fever, headache, chills, and pain at the injection site are the most typical symptoms people experience after getting the Moderna vaccine.

These reactions are temporary and non-threatening. They only indicate that the vaccine is working within your immune system. These side effects typically resolve within a couple of days.

The vaccine trains your immune system to build antibodies. The pain is a symptom of the inflammation that develops as the antibodies develop.

Of course, like other vaccines, the responses may be different. For example, older adults may experience minimal side effects after vaccination compared to younger adults.

Recent data shows that side effects are more common among women.

We do not fully understand the variation in side effects between genders. Some experts think that it is a biological component, while others believe that women are more likely to report side effects.

Some people may have anaphylaxis. It is a severe but rare allergic reaction. Anaphylaxis appears to be more prevalent in women.


Side effects are more intense after the second dose

It is important to note that the Moderna vaccine is a messenger RNA vaccine. It teaches your body cells how to create a piece of SARS-CoV-2 protein and wage an immune response against it.

So, if you’re exposed to the virus, your body will be able to recognize it and fight against it to prevent disease.

The initial dose of the Moderna COVID-19 vaccine is considered “the prime.” This first dose trains your body on how to recognize the virus. Reactions to the first exposure are typically mild. The second dose is the “booster.” The booster dose cements the response by your immune system.

Studies have also shown that people who have previously had COVID-19 tend to react more intensely since they technically have some level of immunity.


Reactions to Moderna vaccine vs. other shots

The side effects of the Moderna vaccine are almost the same as those of the Pfizer vaccine. Pfizer vaccine is in itself an mRNA vaccine.

Recipients of both vaccines experience pain at the site of injection. They also experience redness. Both side effects show up after the first dose. The second dose is accompanied by joint pain and fatigue.



With over 219.8 million people vaccinated in the United States, we’re seeing an obvious picture of the side effects of the COVID-19 vaccine.

Common side effects experienced include pain at the injection site and redness. These usually occur after the first dose. The second dose is accompanied by joint pain and fatigue.

People experience more intense reactions after the second dose. Responses are also lower in people who have already had COVID-19.

These reactions are normal and indicate that the vaccine is working – teaching your immune system how to fight the virus.

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